CLASSICS OF IMMUNOLOGY

CLASSICS OF IMMUNOLOGY

SCIENTIFIC PAPERS

Jenner, E

1798 An Inquiry into the Causes and Effects of Variolae Vaccinae, a Disease Discovered in Some Western Counties of England.
London, Sampson Low; 1798.

http://www.foundersofscience.net/inqparta.pdf

Schwann, T

1837 Preliminary report on experiments concerning alcoholic fermentation and putrefaction.

http://www.spaceship-earth.org/OrigLit/Schwann01.htm

Cagnniard-Latour, C.

Memoir on alcoholic fermentation

1838 Memoire sur la fermentation vineuse. Annales de chimie et de physique, Vol. 68, pages 206-222.

http://www.spaceship-earth.org/OrigLit/Cagniard.htm

Semmelweis, I

1850 Lecture on the genesis of Puerperal Fever (childbed fever)

In Milestones in Microbiology: 1556 to 1940, translated and edited by ThomasD.Brock, ASM Press. 1998, p 80

Pasteur, L

1857 Report on the lactic acid fermentation.

http://www.spaceship-earth.org/OrigLit/Pasteur1.htm

1860 Memoir on the alcoholic fermentation.

http://www.spaceship-earth.org/OrigLit/Pasteur2.htm

1861 Influence of oxygen on the development of yeast and on the alcoholic fermentation. (ABSTRACT)

http://www.spaceship-earth.org/OrigLit/Pasteur4.htm

1861 On the organized bodies which exist in the atmosphere; examination of the doctrine of spontaneous generation

http://ce.ecn.purdue.edu/~piwc/w3-history/pasteur/pasteur.html.

Lister, J

1867 On a new method of treating compound fracture, abscess, etc. with observations on conditions of supparations.

In Milestones in Microbiology: 1556 to 1940, translated and edited by Thomas Brock, ASM Press 1998, p83

1867 On the antiseptic principle in the practice of surgery.

http://www.bartleby.com/38/6/1.html

Pasteur, L

1870 The Physiological Theory of Fermentation

Reply to the Critical Observations of Liebig, Published in 1870:www.bartleby.com/38/7

Koch, R

1876 The Etiology of Anthrax, Based on the Life History of Bacillus anthracis. Beitrage zer Biologie der Ppanzen, 1876 , Vol. 2, No. 2, pages 277-310.

In Milestones in Microbiology: 1556 to 1940, translated and edited by Thomas D. Brock, ASM Press. 1998, p89 [PDF]

Pasteur, L

1878 La théorie des germes et ses application à la médecine et à la chirurgie (avec la collaboration de MM.
Joubert et Chamberland)", C.R.. Acad. Sci., 29 avril 1878, LXXXVI, pp. 1037-1043.

Physiology: The Theory of Germs and its Application to Medicine and Surgery; with the collaboration of MM.

Joubert et Chamberland. Translated by Dr. Nila Mummneh [PDF]

1880 Sur les maladies virulentes, et en particulier sur la maladie appelée vulgairement choléra des poules", C. R. Acad. Sci., 1880, XC, pp.239-248.

Physiologic Chemistry: Of Infectious Diseases, Especially the Disease of Chicken Cholera.Translated by Dr. Nila Mummneh [PDF]

De l'extension de la théorie des germes à l'étiologie de quelques maladies communes ( I. "Sur les furoncles. II. "Sur

l'ostéomyélite.III. "Sur la fièvre puerpérale.)", C.R. Acad.Sci., 3 mai 1880, XC, pp. 1033-1044

On the Extension of the Germ Theory to the Etiology of Certain Common Diseases:[http://www.bartleby.com/]

1881 "De l'atténuation des virus et de leur retour à la virulence avec la collaboration de MM Chamberland et Roux", C. R. Acad. Sci., 28 février 1881, XCII, pp. 429-435.

General Pathology: About the Attenuation of Viruses and Regaining their Virulence; with the collaboration of MM Chamberland

and Roux. Translated by Dr. Nila Mummneh [PDF]

"Compte rendu sommaire des expériences faites à Pouilly-Le-Fort, près de Melun, sur la vaccination charbonneuse (avec la collaboration de MM. Chamberland et Roux)", C. R. Acad. Sci., 13 juin 1881, XCII, pp. 1378-1383.

Summary Report of the Experiments Conducted at Pouilly-le-Fort, Near Melun, on the Anthrax Vaccination, with the collaboration of Mr. Chamberland and Mr. Roux. Translated by Tina Dasgupta, Yale School of Medicine, Original Contributions Editor, Yale Journal of Biology and Medicine. [PDF]

Koch, R

1884 The Etiology of Tuberculosis [Koch's postulates.] Mittheilungen aus dem Kaiserlichen Gesundheisamte, 1884, Vol. 2, pp. 1-88

In Milestones in Microbiology: 1556 to 1940, translated and edited by Thomas D. Brock, ASM Press. 1998, p 116. p116 [PDF]

Metschnikoff, E

1884 A disease of Daphnia caused by a yeast. A contribution to the theory of phagocytes as agents for attack on disease-causing organisms. Arcbiv f. patbologiscbe Anutomie und Pbysiologie und fkliniscbe Medicin,Vol. 96, pages 177-195.

Milestones in Microbiology: 1556 to 1940, translated and edited by Thomas D. Brock, ASM Press. 1998, p 132.-138 [PDF]

Pasteur, L

1885 Méthode pour prévenir la rage après morsure". C. R. Acad. Sci., 26 octobre 1885, CI, pp.765- 773 et pp. 765-773 et p. 774

Method for Preventing Rabies After a Bite. Translated by E.T and D.V. Cohn. [PDF]

Behring, EA von & Kitasato, S

1890 Aus dem hygienischen Institut des Herrn Geheimerath Koch in Berlin : Ueber das

Zustandekommen der Diphtherie-Immunitat under Tetanus-Immunitat bei Thieren, 4 December 1890 , 49

From the hygeinic institute of Hern Geheimerath Koch in Berlin: Concerning Development of Diphtheria Immunity and Tetanus Immunity in Animals. Translated by Dr. Michael Jacobson. [PDF]

Coley, WB.

1893 The Treatment of Malignant Tumors By Repeated Inoculations of Erysipelas: With A Report of Ten Original Cases

The American Journal of Medical Sciences. 1893;10:487-511. (May, 1893). [PDF]

Wright, Sir A E & Semple, Sir D

1897 Remarks on Vaccination Against Typhoid Fever

British Medical Journal i: 256-259.

Ehrlich, P

1900 Croonian Lecture: On Immunity with Special Reference to Cell Life.

Proceedings Of the Royal Society of London, Vol. 66. (1899-1900), pp. 424-448 [PDF]

Laudsteiner, K

1901 Ueber agglutinationserscheinungen normalen menschlichen Blutes.

Wien. Klin. Wochenschr: 12:1132-1134

Translation: On agglutination phenomena of normal human blood, in S.H. Boyer (Editor), 1963, Papers on Human

Genetics,pp.27-31. Prentice-Hall, Englewood Cliffs, NJ [PDF]

Metchnikoff, M

1901 Sur l'Existence de Substances sensibilisatrices Dans La Plupart Des Serums Antimicrobiens

Portier, P & Richet, C

1902 De l'action anaphylactique de quelques venins.

Comptes Rendus de Societe Biologique 1902; 54:170-172 (In French)

Arthus, M

1903 Injections repetees de serum de cheval le lapin.

Seances et Memoire de la Societe de Biologie 55: 817-80 (In French)

Von Pirquet, C. Frh & Schick, B

1908 Serum Sickness

Baltimore, Williams & Wilkins, 1951, vii-121

Calmette A, Guerin, C

1924 Vaccination des bovidés contre la tuberculose et méthode nouvelle de prophylaxie de la tuberculose bovine.

Annales de l'Institut Pasteur, Paris, 1924, 38: 371-398 (In French)

Shope, R.E.

1931 Swine influenza: I. Experimental transmission and pathology

J. Exp. Med. 1931 54: 349-359

Lewis P.A. and Shope, R.E.

1931 Swine influenza. II. A hemophilic bacillus from the respiratory tract of infected swine

J. Exp. Med. 1931 54: 361-371

Smith W, A CH, Laidlaw PP.

1933 A virus obtained from influenza patients.

Lancet. 1933;2:66–8

Landsteiner, K and van der Scheer, J

1935 On Cross Reactions Of Immune Sera To Azoproteins

J Exp Med. 1936;63(3):325-339,

Theiler M, Smith HH

1937 The Use of Yellow Fever Virus Modified by in Vitro Cultivation for Human Immunization.

J Exp Med. 1936; 65: 787-800

Tiselius, A Kabat, E. A.

1939 An Electrophoretic Study of Immune Sera and Purified Antibody Preparations

J Exp Med 65: 119-131

Freund, J & McDermott, K

1942 Sensitization to horse serum by means of adjuvants

Proc. Soc. Exp. Biol. Med. N.Y.; 49:548-553

Medawar, P B.

1944 The behaviour and fate of skin autografts and skin homograts in rabbits

Journal of Anatomy, 78: 176-199.

Chase, M

1945 The cellular transfer of cutaneous hypersensitivity to tuberculin

Proc. Soc. Exp. Biol. Med. 59: 134

Owen, RD

1945 Immunogenetic consequences of vascular anastomoses between bovine twins.

Science 102: 400

Fagraeus, A

1948 The Plasma Cellular Reaction and its Relation to the Formation of Antibodies In Vitro

J. Immunol. 58:1–13

Bruton , O

1952 Agammaglobulinemia

Pediatrics 1952 9 (6): 722-728

Billingham, RE.;Brent, L. & Medawar, P. B. F.R.S.

1953 Actively Acquired Tolerance of Foreign Cells

Nature 1953;172:603-606 -Reprinted in Volume 76(10), 27 November 2003, pp 1409-1412

Jerne, N K.

1955 The Natural-Selection Theory of Antibody Formation.

PNAS 1955 41: 849-857

Salk, J

1955 1955 Polio Vaccine Trial Announcement

http://www.sph.umich.edu/about/polioannouncement.html

Glick, B

1956 The Bursa of Fabricius and antibody production

Poultry Science 1956; 35:224-225

Burnet, FM

1957 A Modification of Jerne's Theory of Antibody Production Using the Concept of Clonal Selection

Australian Journal of Science. 20, 67-69.

Reprinted in CA Cancer J Clin. 1976 Mar-Apr;26(2):119-21

Issacs, A & Lindemann, J

1957 Virus Interference I. The Interferon

Proceedings of the Royal Society of London B 147:258-267

Benacerraf B, & Gell PG

1959 Studies on Hypersensitivity. I. Delayed and Arthustype Skin Reactivity to Protein Conjugates in Guinea Pigs.

Immunology. 1959 Jan;2(1):53-63

Porter, R

1959 The Hydrolysis of Rabbit y-Globulin and Antibodies with Crystalline Papain

Biochem J. 1959 Sep;73:119-26.

Nowell, P.

1960 Phytohemagglutinin: An Initiator of Mitosis in Cultures of Normal Human Leukocytes

Cancer Res. 1960 May;20:462-6

Edelman, G & Poulik, M

1961 Studies on structural units of the gamma-globulins

J. Exp. Med. 1961 113: 861-884

Nowell, Peter C.

1961 Inhibition of Human Leukocyte Mitosis by Prednisolone in Vitro

Cancer Res. 1961 Dec;21:1518-21.

Miler J. F.A.P.

1961 Effect of neonatal thymectomy on the immunological responsiveness of the mouse.

Proceedings of the Royal Society of London B 1962; 156B: 415-428.

Jerne NK & Nordin AA

1963 Plaque formation in agar by single antibody-producing cells.

Science. (New Series) 1971 Apr 26;140(565):405

Kantor FS, Ojeda A, Benacerraf B:

1963 Studies on artificial antigens I. Antigenicity of DNP-polylysine and DNP copolymer of lysine and glutamic acid in guinea pigs.

J Exp Med 1963, 117:55-64.

Cooper, MD; Peterson, RDA; Good, RA

1965 A New Concept of the Cellular Basis of Immunity

(Abstract) J. Pediat. 67: 907-908, 1965

Kasakura S & Lowenstein L

1965 A Factor Stimulating DNA Synthesis derived from the Medium of Leucocyte Cultures

Nature. 1965 Nov 20;208:794-795.

MacLean, LD, Gordon J

1965 A Lymphocyte-Stimulating Factor Produced In Vitro

Nature 1965 Nov 20;208:795-796.

Wheelock E F.

1965 Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin

Science. (New Series) 1965;149:310–311

Green I, Paul WE, Benacerraf B

1966 The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in non-responder guinea pigs.

J Exp Med 1966, 123:859-879

Schlossman S, Ben-Efraim S, Yaron A, Sober H

1966 Immunochemical studies on the antigenic determinants required to elicit delayed and immediate hypersensitivity reactions.

J Exp Med 1966, 123:1083-1095

Ishizaka, K & Ishizaka T

1967 Identification of gamma-E-antibodies as a carrier of reaginic activity

Journal of Immunology 1967; 6:1187-1198

Mishell RI, Dutton RW.

1967 Immunization of dissociated spleen cell cultures from normal mice.

J Exp Med. 1967 Sep 1;126(3):423-42

Mosier, Donald E.

1967 A Requirement for Two Cell Types for Antibody Formation in Vitro

Science. (New Series) 1967 Dec 22;158(808):1573-5

Brunner KT, Mauel J, Cerottini JC, Chapuis B.

1968 Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro;
inhibition by isoantibody and by drugs.

Immunology. 1968 Feb;14(2):181-96

McDevitt HO, Tyan ML

1968 Genetic control of the antibody response in inbred mice: Transfer of response by spleen cells and linkage to the
major histocompatability (H2) locus.

J Exp Med 1968, 128:1-11

Unanue E, Askonas BA

1968 Persistence of immunogenicity of antigen after uptake by macrophages.

J Exp Med 1968., 127

McDevitt HO, Chinitz A

1969 Genetic control of the antibody response: Relationship between immune response and histocompatability (H-2) type.

Science 1969, 163:1207-1208.

Hoffman, M & Dutton, RW

1971 Immune Response Restoration with Macrophage Culture Supernatants

Science. (New Series) 1971 Jun 4;172(987):1047-8.

Gery, Igal, Gershon, Richard K., & Waksman, Byron H.

1972 Potentiation of the T-Lymphocyte Response To Mitogens: I.. The Responding Cell

J Exp Med. 1972 Jul 1;136(1):128-42.

Gery I, Waksman BH.

1972 Potentiation of the T-lymphocyte Response to Mitogens. II. The Cellular Source of Potentiating Mediator(s).

J Exp Med. 1972 Jul 1;136(1):143-55

Schimpl, A. & Wecker, E.

1972 Replacement of T-Cell Function by a T-Cell Product.

Nat New Biol. 1972 May 3;237(70):15-7

Wagner, H and Feldmann, M

1972 Cell-mediated immune response in vitro ^, : I. A new in vitro system for the generation of cell-mediated cytotoxic activity

Cellular Immunology, Volume 3, Issue 3, March 1972, Pages 405-420

Katz DH, Hamaoka T, Dorf ME, Benacerraf B.

1973 Cell interactions between histoincompatible T and B lymphocytes II. Failure of physiologic cooperative
interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates.

J Exp Med. 1973 Jun 1;137(6):1405-18

Rosenthal A, Shevach E

1973 Function of macrophages in antigen recognition by guinea pig T lymphocytes. I. Requirement for histocompatible macrophages and lymphocytes.

J Exp Med 1973, 138:1194-1212.

Steinman RM, Cohn ZA.

1973 Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution.

J Exp Med. 1973 May 1;137(5):1142-62.

Lindahl P, Leary P, Gresser I

1974 Enhancement of the expression of histocompatibility antigens of mouse lymphoid cells by interferon in vitro

Eur. J. of Immunology Volume 4, Issue 12, 1974. Pages 779-784

Macdonald HR, Engers HD, Cerottini JC, Brunner KT.

1974 Generation of Cytotoxic T Lymphocytes in Vitro. II. Effect of Repeated Exposure to Alloantigens on the Cytotoxic
Activity of Long-Term Mixed Leukocyte Cultures.

J Exp Med. 1974 Sep 1;140(3):718-30

Zinkernagel RM, Doherty PC

1974 Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system.

Nature. 1974 Apr 19;248(450):701-2.

Ben-Sasson SZ, Paul WE, Shevach EM, Green I.

1975 In Vitro Selection and Extended Culture of Antigen-Specific T Lymphocytes. I. Description of Selection Culture Procedure and Initial Characterization of Selected Cells.

J Exp Med. 1975 Jul 1;142(1):90-105.

Herberman RB, Nunn ME, Holden HT, Lavrin DH

1975 Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. II. Characterization of effector cells.

Int J Cancer 1975, 16:230-239

Kiessling R, Klein E, Wigzell H

1975 Natural killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia
cells. Specificity and distribution according to genotype

Eur J Immunol 1975, 5:112-116

Kisielow P, Hirst JA, Shiku H, Beverley PC, Hoffman MK, Boyse EA, Oettgen HF.

1975 Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse

Nature. 1975 Jan 17;253(5488):219-20

Kohler G, Milstein C

1975 Continuous culture of fused cells secreting antibody of predefined specificity.

Nature 1975, 256:495-499

Svedmyr E.

1975 Long-Term Maintenance In Vitro of Human T Cells by Repeated Exposure to the Same Stimulator Cells Differences When Using Repeated Stimulation in Allogeneic Mixed Leukocyte Culture and When Using Stimulation with Autologous Lymphoblastoid Cells.

Scand J Immunol. 1975 Sep;4(5-6):421-7.

Dennert G, De Rose M.

1976 Continuously Proliferating T Killer Cells Specific for H-2b Targets: Selection and Characterization.

J Immunol. 1976 Jun;116(6):1601-6.

Green S, Dobrjansky A, Carswell EA, Kassel RL, Old LJ, Fiore N, & Schwartz, MK

1976 Partial Purification of a Serum Factor that Causes Necrosis of Tumors

PNAS 1976 73: 381-385

Hozumi N, Tonegawa S:

1976 Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions.

Proc Natl Acad Sci U S A 1976, 73:3628-3632

Lindahl P, Gresser I, Leary P, Tovey M.

1976 Enhanced Expression of Histocompatibility Antigens of Lymphoid Cells in Mice Treated with Interferon.

J Infect Dis. 1976 Jun;133 Suppl:A66-8

Morgan DA, Ruscetti FW, Gallo R

1976 Selective in vitro growth of T lymphocytes from normal human bone marrows.

Science 1976, 193:1007-1008.

Plate JM

1976 Soluble Factors Substitute for T-T-Cell Collaboration in Generation of T-killer Lymphocytes.

Nature. 1976 Mar 25;260(5549):329-31.

Burgess A, Camakaris J, Metcalf D

1977 Purification and properties of colony-stimulating factor from mouse lung-conditioned medium.

J Biol Chem 1977, 252:1998-2003

Gillis S, Smith KA

1977 Long Term Culture of Tumour-Specific Cytotoxic T Cells

Nature 1977, 268:154-156

Tonegawa S, Brack C, Hozumi N, Schuller R

1977 Cloning of an immunoglobulin variable region gene from mouse embryo.

Proc Natl Acad Sci U S A 1977, 74:3518-3523

Bernard O, Hozumi N, Tonegawa S

1978 Sequences of mouse immunoglobulin light cain genes before and after somatic changes.

Cell 1978, 15:1133-1139

Gillis S, Ferm MM, Ou W, Smith KA.

1978 T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

J Immunol. 1978 Jun;120(6):2027-32.

Gillis S, Baker PE, Ruscetti FW, Smith KA.

1978 Long-term culture of human antigen-specific cytotoxic T-cell lines.

J Exp Med. 1978 Oct 1;148(4):1093-8.

Seidman J, Edgell M, Leder P

1978 Immunoglobulin light chain structural gene sequences cloned in a bacterial plasmid.

Nature 1978, 271:582-586

Baker PE, Gillis S, Smith KA

1979 Monoclonal Cytolytic T-cell lines.

J Exp Med. 1979 Jan 1;149(1):273-8.

Gillis S, Crabtree GR, Smith KA

1979 Glucocorticoid-Induced Inhibition of T cell Growth Factor Production. I. The Effect on Mitogen-Induced Lymphocyte Proliferation.

J Immunol. 1979 Oct;123(4):1632-8

Reinherz EL, Kung PC, Goldstein G, Schlossman SF.

1979 Separation of Functional Subsets of Human T Cells by a Monoclonal Antibody.

Proc Natl Acad Sci U S A. 1979 Aug;76(8):4061-5

Dennert G.

1980 Cloned Lines of Natural Killer Cells.

Nature. 1980 Sep 4;287(5777):47-9

Smith KA, Gilbride KJ, Favata MF

1980 Lymphocyte Activating Factor Promotes T-cell Growth Factor Production by Cloned Murine Lymphoma Cells

Nature. 1980 Oct 30;287(5785):853-5.

Smith KA, Lachman LB. Oppenheim, JJ and Favata, MF

1980 The Functional Relationship of the Interleukins

J Exp Med. 1980 Jun 1;151(6):1551-6.

Bunjes D, Hardt C, Rollinghoff M, Wagner H

1981 Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1

and interleukin 2.

Eur J Immunol 1981, 11:657-661

Robb RJ, Munck A, Smith KA.

1981 T Cell Growth Factor Receptors. Quantitation, Specificity, and Biological Relevance

J Exp Med. 1981 Nov 1;154(5):1455-74.

Robb RJ, Smith KA.

1981 Heterogeneity of human T-cell growth factor(s) due to variable glycosylation.

Mol Immunol. 1981 Dec;18(12):1087–1094

Isakson P, Pure E, Vitteta E, Krammer P

1982 T cell-derived B cell differentiation factor(s): effect on the isotype switch of murine B cells.

J Exp Med 1982, 155:734-748

Howard M, Farrar J, Hilfiker M, Johnson B, Takatsu K, Hamaoka T, Paul WE

1982 Identification of a T cell-derived B cell growth factor distinct from interleukin 2.

J Exp Med 1982, 155:914-923

Leonard WJ, Depper JM, Uchiyama T, Smith KA, Waldmann TA, Greene WC.

1982 A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor.

Nature. 1982 Nov 18;300(5889):267-9.

Haskins K, Kubo R, White J, Pigeon, Kappler M, and Marrack P

1983 The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells. I. Isolation With a Monoclonal Antibody.

J. Exp. Med. 1983 157: 1149-1169

1983 McIntyre B, Allison J

The mouse T cell receptor: Structural heterogeneity of molecules of normal T cells defined by xenoantiserum.

Cell 1983, 34:739-746.

Meuer SC, Fitzgerald KA, Hussey RE, Hodgdon JC, Schlossman S, Reinherz EL

1983 Clonotypic Structures Involved in Antigen-Specific Human T Cell Function. Relationship to the T3 Molecular Complex

J Exp Med. 1983 Feb 1;157(2):705-19.

Meuer SC, Hodgdon JC, Hussey RE, Protentis JP, Schlossman S, Reinherz EL

1983 Antigen-Like Effects of Monoclonal Antibodies Directed at Receptors on Human T Cell Clones

J. Exp. Med. 1983 158: 988-993

Schreiber R, Pace J, Russell S, Altman A, Katz D

1983 Macrophage-activating factor produced by a T cell hybridoma: physiochemical and biosynthetic resemblance to gamma-interferon.

J Immunol 1983, 131:826-832

Smith KA, Favata MF and Oroszlan, S

1983 Production and Characterization of Monoclonal Antibodies to Human Interleukin 2: Strategy and Tactics

J Immunol. 1983 Oct;131(4):1808-15

Taniguchi T, Matsui H, Fujita T, Takaoka C, Kashima N, Yoshimoto R

1983 Structure and expression of a cloned cDNA for human interleukin-2.

Nature. 1983 Mar 24-30;302(5906):305-10.

Cantrell DA, & Smith, KA

1984 The Interleukin-2 T-Cell System: A New Cell Growth Model

Science 1984 224:1312-1316

Hedrick SM, Cohen DI, Nielsen EA, Davis MM.

1984 Isolation of cDNA Clones Encoding T Cell-Specific Membrane-Associated Proteins

Nature 1984, 308:149-155

Holbrook NJ, Smith KA, Fornace AJ Jr, Comeau CM, Wiskocil RL, Crabtree GR.

1984 T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells.

Proc Natl Acad Sci U S A. 1984 March; 81(6): 1634–1638

Podack ER, Konigsberg PJ.

1984 Cytolytic T Cell Granules. Isolation, Structural, Biochemical, and Functional Characterization.

J Exp Med. 1984 Sep 1;160(3):695-710

Babbitt BP, Allen PM, Matsueda G, Haber E, Unanue ER.

1985 Binding of Immunogenic Peptides to Ia Histocompatibility Molecules

Nature 1985 Sep 26-Oct 2;317(6035):359-61

Beutler B, Greenwald D, Hulmes JD, Chang M, Pan YC, Mathison J, Ulevitch R, Cerami A.

1985 Identity of tumour necrosis factor and the macrophage-secreted factor cachectin.

Nature. 1985 Aug 8-14;316(6028):552-4.

Beutler B, Mahoney J, Le TN, Pekala P, Cerami A

1985 Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells.

J Exp Med 1985, 161:984-995

Hirano T, Taga T, Nakano N, Yasukawa K, Kashiwamura S, Shimizu K, Nakajima K, Pyun KH, Kishimoto T

1985 Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2).

Proc Natl Acad Sci U S A 1985, 82:5490-5494.

Pennica D, Hayflick J, Bringman T, Palladino M, Goeddel D

1985 Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor

Proc Natl Acad Sci U S A 1985, 82:6060-6064.

Podack ER, Young JD, And Cohn ZA.

1985 Isolation and Biochemical and Functional Characterization of Perforin 1 from Cytolytic T-cell Granules

Proc. Natl. Acad. Sci. USA 82: 8629-8633

1985 Takatsu K, Harada N, Hara Y, Takahama Y, Yamada G, Dobashi K, Hamaoka T

Purification and physicochemical characterization of murine T cell replacing factor (TRF)

J Immunol 1985, 134:382-389

1986 Gately MK, Wilson DE, Wong HL

Synergy between recombinant interleukin 2 (rIL2) and IL2-depleted lymphokine-containing supernatants in facilitating allogeneic human cytolytic T lymphocyte responses in vitro.

J Immunol 1986, 136:1274-1282

Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, and Coffman, RL

1986 Two Types of Murine Helper T Cell Clone. I. Definition According to Profiles of Lymphokine Activities and Secreted Proteins

J Immunol 1986 136: 2348-2357

Sen R & Baltimore D

1986 Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

Cell, Vol 47, 921-928, 26 December 1986

Stern, J., Smith, K

1986 Interleukin-2 Induction of T-Cell G₁ Progression and c-myb Expression

Science, Volume 233, Issue 4760, pp. 203-206

Tracey K, Beutler B, Lowry S, Merryweather J, Wolpe S, Milsark I, Hariri R, Fahey T, Zentella A, Albert J, et al.

1986 Shock and tissue injury induced by recombinant human cachectin.

Science 1986, 234:470-474.

Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC

1987 Structure of the human class I Histocompatibility Antigen, HLA-A2

Nature. 1987 Oct 8-14;329(6139):506-12

Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC

1987 The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens.

Nature. 1987 Oct 8-14;329(6139):512-8.

Brunet JF, Denizot F, Luciani MF, Roux-Dosseto M, Suzan M, Mattei MG, Golstein P

1987 A new member of the immunoglobulin superfamily--CTLA-4.

Nature 1987, 328:267-270

Chien YH, Iwashima M, Kaplan KB, Elliott JF, Davis MM.

1987 A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation.

Nature. 1987 Jun 25-Jul 1;327(6124):677-82.

Jenkins MK, Schwartz RH

1987 Antigen Presentation by Chemically Modified Splenocytes Induces Antigen-Specific T cell Unresponsiveness in Vitro and in Vivo

J Exp Med 1987 Feb 1;165(2):302-19

Kappler JW, Roehm N, Marrack P.

1987 T cell tolerance by clonal elimination in the thymus

Cell. 1987 Apr 24;49(2):273-80.

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1996 A Dominant Role for Mast Cell Fc Receptors in the Arthus Reaction

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1998 Induction and Exhaustion of Lymphocytic Choriomeningitis Virus-specific Cytotoxic T Lymphocytes Visualized
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1998 CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production.

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1999 The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

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1999 Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

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2000 Prevention of rejection in cardiac transplantation by blockade of the interleukin-2 receptor with a monoclonal antibody.

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2000 Biallelic expression of the IL-2 locus under optimal stimulation conditions.

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2000 A Toll-Like Receptor Recognizes Bacterial DNA.

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2000 Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.

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2000 A novel transcription factor, T-bet, directs Th1 lineage commitment.

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2001 Recognition of Double-Stranded RNA and Activation of NF- B by Toll-Like Receptor 3

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2001 The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements.

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2001 How much TCR does a T cell need?.

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2001 Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2.

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2001 IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation.

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2001 Adaptive Tolerance of CD4+ T Cells in Vivo: Multiple Thresholds in Response to a Constant Level of Antigen Presentation

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2002 DNA array analysis of interleukin-2-regulated immediate/early genes.

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2002 DCs Induce CD40-Independent Immunoglobulin Class Switching Through BLyS and APRIL.

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2002 Transcriptional mechanisms underlying lymphocyte tolerance.

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2003 c-Rel is required for chromatin remodeling across the IL-2 gene promoter.

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2004 The quantal theory of how the immune system discriminates between "self and non-self"

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2004 Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function.

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